5,5-Diaryl-2-amino-4-pentenoates as novel, potent, and selective glycine transporter type-2 reuptake inhibitors

M Isaac; A Slassi; K D Silva; J Arora; N MacLean; B Hung; K McCallum

doi:10.1016/s0960-894x(01)00253-0

5,5-Diaryl-2-amino-4-pentenoates as novel, potent, and selective glycine transporter type-2 reuptake inhibitors

Bioorg Med Chem Lett. 2001 Jun 4;11(11):1371-3. doi: 10.1016/s0960-894x(01)00253-0.

Authors

M Isaac¹, A Slassi, K D Silva, J Arora, N MacLean, B Hung, K McCallum

Affiliation

¹ NPS Pharmaceuticals Inc., 6850 Goreway Drive, L4V 1V7, Mississauga, ON, Canada. misaac@npsallelix.com

PMID: 11378357
DOI: 10.1016/s0960-894x(01)00253-0

Abstract

A novel series of 5,5-diaryl-2-amino-4-pentenoates was synthesized and found to be potent and selective glycine transporter type-2 reuptake inhibitors.

MeSH terms

Alkenes / chemical synthesis
Alkenes / chemistry
Alkenes / pharmacology*
Amino Acid Transport Systems, Neutral*
Antimetabolites / chemical synthesis
Antimetabolites / chemistry
Antimetabolites / pharmacology*
Carrier Proteins / antagonists & inhibitors*
Glycine Plasma Membrane Transport Proteins
Structure-Activity Relationship

Substances

Alkenes
Amino Acid Transport Systems, Neutral
Antimetabolites
Carrier Proteins
Glycine Plasma Membrane Transport Proteins